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Life Skill Personal Self Awareness (Kecakapan Mengenal Diri)

Life Skill Personal Self Awareness juga penting dalam hal mendukung Kebijakan Hukum Pidana dengan pendekatan humanistis. Mengingat problema kejahatan, dengan berbagai modus operandi, baik kejahatan biasa maupun kejahatan luar biasa (extra ordinary crime). Kebijakan hukum pidana yang ditulis dalam buku Prof. Barda Nawawi menyebutkan ‘sebagai upaya nonpenal dalam kebijakan penanggulangan kejahatan, yaitu prevention without punishment, antara lain kesehatan jiwa/mental. Kata Sudarto, “Kalau membicarakan pidana maka harus membicarakan diri orang yang melakukan kejahatan....jadi pembaharuan hukum pidana tetap berkisar pada diri manusia

Kalau seseorang memiliki pemahaman diri yang baik, maka akan menyadari
kekuatan, karena mampu mengembangkan kemampuan; mengenal kelemahan
agar kegagalan tak berulang; Tumbuh dengan kesadaran yang mantap, karena
itu mampu dan puas menjadi seorang „pribadi‟; terbuka untuk menerima dikritik;
dan mau belajar. Memahami diri akan membentuk citra diri. Jika citra diri positif,
akan mengalami hal-hal positif sesuai dengan apa yang dipikirkan. Banyak ahli ...

Well being : a personal plan for exploring and enriching the seven dimensions of life : mind, body, spirit, love, work, play, the Earth

Eight Life-Enriching Practices of United Methodists

This resource is a summary study of the eight life-enriching practices that are part of the series--prayer, Bible study, evangelism, community, worship and the sacraments, outreach, justice and others. Questions for discussion are included with each chapter.

This resource is a summary study of the eight life-enriching practices that are part of the series--prayer, Bible study, evangelism, community, worship and the sacraments, outreach, justice and others.

14-3-3zeta Mediates the Recruitment of ARHGEF2 Onto ROR1 to Facilitate Wnt5a-induced CLL Proliferation/migration

Chronic lymphocytic leukemia (CLL) is one of the most common leukemia that derives from the mutations of B lymphocyte. Previous research has shown that the receptor tyrosine kinase-like orphan receptor 1(ROR1), the receptor expressed specifically by the CLL, is induced to recruit guanine nucleotide exchange factors 2 (ARHGEF2) once activated by Wnt5a, the ligand that bind and activates ROR1 to promote the proliferation and migration of CLL. However, the mechanism for recruiting ARHGEF2 remain unclear. In this study, we found that 14-3-3[zeta], one isomer of the 14-3-3 scaffold protein family, helps to recruit guanine nucleotide exchange factor 2 (ARHGEF2), on to the ROR1 receptor in CLL. Here, we reveal that 14-3-3[zeta] interacts with both ROR1 and ARHGEF2 separately in CLL. Upon Wnt5a stimulation, 14-3-3[zeta] is anchored onto ROR1 via its S857 motif. Also, 14-3-3[zeta] is required for the Wnt5a-induced recruitment of ARHGEF2 onto ROR1. Lastly, 14-3-3[zeta] is necessary for the RhoA/Rac1 activation by ARHGEF2 and proliferation/migration induced by RhoA/Rac1 activation. Collectively, 14-3-3[zeta] mediates the recruitment of ARHGEF2 onto ROR1, which facilitates the Wnt5a-induced CLL proliferation/migration.

Chronic lymphocytic leukemia (CLL) is one of the most common leukemia that derives from the mutations of B lymphocyte.

A Cost of Illness and Quality of Life Study in Patients with B-cell Chronic Lymphocytic Leukemia (CLL) in the Netherlands