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Achieving a Transcendent Episode: A Case Study of the Theological Task Force for Peace, Unity and Purity of the Presbyterian Church (U.S.A.), and Their Final Report

Using the concepts and heuristics of the Coordinated Management of Meaning (CMM), this study reveals the communication patterns inherent in this moral conflict. It also shows how the task force changed those patterns to transcend differences and create a way for others to "go on" in the conversation.

The PUPTF acknowledges that this work took a lot of time and effort, and
commitment. They stuck with the task even at personal cost to themselves. Time
and commitment are two key factors in creating a transcendent episode. This
includes ...

Deliberation and the Equity Task Force in the Madison Metropolitan School District

This dissertation follows the argument that one of the central tenets of deliberative democracy is that reciprocity, the exchange of moral reasons, is required for an effective deliberative process. However, reciprocity and reason exchange do not happen spontaneously. Instead, these processes, which occur largely in formal meetings, must be nurtured in settings that are designed to encourage positive communicative interactions.

Before engaging in a discussion of the charge, the board needed to determine
the goal and its own commitment to the process and then determine the
appropriate method to meet that goal and commitment. Using the IAP2 Spectrum
could ...

Impact to Alternative Contracting Methods Using Multivariate Analysis in the Regulatory Environment

This research addresses legislative impediments inherent to working in the government construction industry by investigating whether benefits exist when using alternative project delivery methods, and whether legislative limitations allowing the use of alternative project delivery methods impede any such benefits from being realized. The research begins by defining the project delivery method process, and explains in detail the four primary types and how they function. The research then provides a qualitative study that presents the perceived advantages and disadvantages of each method. Then, as second literature review provides an overview of previously published research in project delivery method selection, and examines federal and state legislative trends to establish the growing debate associated with alternative project delivery methods, focusing on the design-build mehtod of project delivery. Finally a quantative analysis is presented to test whether federal and state legislative limitations influence the realization of any benefits of alternative project delivery methods, and specifically design-build, for federal projects. Project characteristics from the U.S. General Services Administration Capital Construction Project database are tested. The research suggests that when an alternative project delivery method, specifically design-build, is chosen, there are benefit in time and cost savings, and the ability to use the alternative project delivery method is affected by the removal of federal and state legislative impediments.

/MISSING MEANSUB /STATISTICS COEFF OUTS CI R ANOVA COLLIN TOL
CHANGE /CRITERIA=PIN(.05) POUT(.10) /NOORIGIN /DEPENDENT DMOrig /
METHOD=ENTER Region ProjectTypeOriginal ProgramOriginal
FederalLaws1996 ...

A Comparison of the Aptitude and Attitude of College Students Toward Social and Technical Computer Technology

Colleges and universities as well as industry are taking advantage of social technology not only for recruitment but in the classroom and on the job as well. A strong relationship between social and technical aptitude and social and technical attitude would tend to indicate that students are ready for this type of interaction.

... cell-phones, message boards (Ching, Basham, & Fang, 2005). 5. Competency:
the capability or ability to do a task (Collin, 1992). 6. Computer aptitude: the
cumulative effect of exposure to computers and related events (Palaigeorgiou et.
al, ...

Syntheses, X-ray Structures, Spectroscopy, DFT Electronic Configuration, and Biological Relevance of Photolabile Ruthenium and Iron Nitrosyls Derived from Ligands Containing Carboxamido-N Donors

The next two chapters (Chapters 2 and 3) describe our efforts towards isolating Ru-based NO donors that are sensitive to visible light, instead of UV light. Such complexes are potentially much more useful in biological NO transfer experiments, or as potential therapeutics in photodynamic therapy (PDT). One major focus has been the direct coordination of visible-light-harvesting chromophores to the Ru-center, which has aided in photosensitizing Ru-nitrosyls up to wavelengths of 600 nm (red light).

Biochem. 99 (2005) 1458. [75] E. Baranoff, J.-P. Collin, L. Flamigni, J. -P.
Sauvage, Chem. Soc. Rev. 33 (2004) 147. [76] E. Tfouni, Coord. Chem. Rev. 196
(2000) 281. [771 (a) B. Durham, S. Wilson, D. Hodgson, T.J. Meyer, J. Am. Chem.
Soc.

Scientific Misconduct: Perceptions, Beliefs, Working Environments, and Reporting Practices in the Clinical Research Associate Population

The purpose of this research study was to survey clinical research associates (CRAs) to obtain information on their attitudes, beliefs, experiences, and reporting practices related to scientific misconduct in clinical trials. This research extended the research conducted by a group of investigators at the University of Alabama (Pryor, E. R., Habermann, B., & Broome, M. E. [in press]. Scientific misconduct from the perspective of research coordinators: A national survey. Journal of Medical Ethics). Data were collected using the Scientific Misconduct Questionnaire-Revised (2), adapted from the questionnaire used by Pryor et al. There were 108 evaluable responders (13.8%) from 783 deliverable surveys sent to CRAs in the Constella Group, LLC, CRA database. Overall, the perceived frequency of misconduct was low except in two areas: protocol violations and adverse event reporting. Observed scientific misconduct by an investigator was reported by 20% of the respondents, and observed misconduct by other research personnel was reported by 17% of the respondents. CRAs with the least experience (0 to 5 years) were more aware of misconduct than more experienced CRAs. CRAs reported misconduct when they observed it, and almost all of them thought their fellow CRAs also would report observed incidents of scientific misconduct. Site environmental influences and individual behavioral influences were perceived to have an impact on scientific misconduct. These findings were exploratory and expanded the body of knowledge on scientific misconduct to the CRA population. However, because of the low response rate, the results are limited in how they can be generalized to the CRA population.

Ethics and Bioethics Webster's Student Dictionary defines ethics as “moral
principles” (Collin, 1999, p. 152). According to Riis (2001), ethics are “the
collection of fundamental values, attitudes, and norms considered by most of the
population ...

Pragmatic and Dialectic Mixed Method Approaches: An Empirical Comparison

The pragmatic mixed method study was developed by integrating a post-positivistic telephone survey with weakly interpretive focus groups at the point of interpretation using pragmatic criteria. The dialectic study mixed the same post-positivistic telephone survey with strongly interpretive phenomenological interviews using a Hegelian-inspired dialectic format. All three single methods were examined by a method expert in the field who affirmed the methodologies used.

247 Feedback on Mixed Method Studies #1 and #2 Please read the Method Mix
1 and Method Mix 2 documents provided with this survey. Mixed Mix 1
summarizes and combines the findings of the telephone survey and focus group
methods.

Data-driven Methods for the Analysis of Time-resolved Mental Chronometry FMRI Data Sets: Approaches and Techniques Based on the Fuzzy Clustering Method and Spatial Independent Component Analysis

Finally, the findings obtained in the context of the simulated data set are applied to the analysis of the visuo-spatial mental imagery data sets with both methods. This approach allows to determine and interpret the differences between corresponding topological structures obtained by both methods. (Abstract shortened by UMI.)

Finally, the findings obtained in the context of the simulated data set are applied to the analysis of the visuo-spatial mental imagery data sets with both methods.

Machine Learning Approaches for Epitope Prediction

The development of reliable epitope prediction tools is not feasible in the absence of high quality data sets. Unfortunately, most of the existing epitope benchmark data sets are comprised of epitope sequences that share high degree of similarity with other peptide sequences in the same data set. We demonstrate the pitfalls of these commonly used data sets for evaluating the performance of machine learning approaches to epitope prediction. Finally, we propose a similarity reduction procedure that is more stringent than currently used similarity reduction methods.

Based on our results, we propose FBCPred, a method for predicting flexible
length linear B-cell epitopes using string kernels. The results have been
published in the 7th International Conference on Computational Systems Bioinfor
- matics ...

Part One. Synthesis of Optically Active Tryptophan Derivatives with Potential Activity as Indoleamine 2,3-dioxygenase Inhibitors: An Approach Via Asymmetric Catalytic Hydrogenation. Part Two. Design, Synthesis and Pharmacology of Selective Ligands for Alpha1-containing GABA(A)/benzodiazepine Receptor Subtypes: SAR Studies of Beta-carbolines at Positions -3 and -6 and Their Corresponding Bivalent Ligands. Part Three. First Enantiospecific Total Synthesis of the Important Biogenetic Intermediates, (+)-polyneuridine and (+)-polyneuridine Aldehyde, as Well as 16-epi-vellosimine and Macusine A.

Part III. The first stereospecific total synthesis of (+)-polyneuridine aldehyde 17, 16-epivellosimine 19, (+)-polyneuridine 22 and macusine A 23 has been accomplished from commercially available D-(+)-tryptophan methyl ester. D-(+)-Tryptophan has served here both as the chiral auxiliary and the starting material for the synthesis of the common intermediate, (+)-vellosimine 27. This alkaloid was available in enantiospecific fashion in seven reaction vessels in 27% overall yield from D-(+)-tryptophan methyl ester 28 via a combination of the asymmetric Pictet-Spengler reaction, Dieckmann cyclization, and a stereocontrolled intramolecular enolate-driven palladium-mediated cross-coupling reaction. An enantiospecific total synthesis of (+)-polyneuridine aldehyde 17, which was proposed as an important biogenetic intermediate in the biosynthesis of quebrachidine 6, was then accomplished in an overall yield of 14.1% in 13 reaction vessels from D-(+)-tryptophan ethyl ester 28. Aldehyde 27 was protected as the Na-Boc aldehyde 63, and then converted into the prochiral C (16)-quaternary diol 64 via the practical Tollens' reaction and deprotection. The DDQ-mediated oxidative cyclization and TFA/Et3SiH reductive cleavage served as protection/deprotection step to provide a versatile entry into the three alkaloids, polyneuridine aldehyde 17, polyneuridine 22 and macusine A 23 from quarternary diol 26. The chemospecific and regiospecific oxidations of the 16-hydroxymethyl group contained in the axial position in contrast to the equatorial hydroxymethyl group was achieved with the Corey-Kim reagent to provide the desired aldehydes, polyneuridine aldehyde 17 and 16-epi-vellosimine 19 with absolute diastereoselectivity.

Objectives and synthetic approach The unique and complex architecture of the
above-mentioned indole alkaloids, coupled with their largely unexplored
potential in medicine or as tools for biological studies, make these compounds
attractive ...