Jadi cowok gantle adalah impian kaum Adam yang pengen dipuji dan jadi idola. Segala usaha dilakuin kaum cowok demi demi memenuhi kriteria cowok gantle tadi. Sssstt...Buku ini juga penting dibaca oleh para cewek yang pengen tahu gimana sih "daleman" cowok. So, buruan para cowok baca ni buku, sebelum cewek mengetahui semua rahasiamu. [DAR! Mizan, Remaja, Referensi, Indonesia]
This thesis presents the total synthesis of the natural product acremolin and its structural reassignment along with attempts towards synthesizing analogues of natural product. Acremolin is a natural product reported as a 1H-azirine-containing guanine derivative isolated from Acremonium strictum. Due to the known structural instability of 1H-azirines systems, the original assignment is highly improbable. Two alternative structures were proposed based on the evaluation of spectroscopic data reported for the natural product. Both isomers were synthesized from guanine and the structure of the natural product was reassigned as N2, 3-etheno-2'-isopropyl-1-methylguanine based on matching spectroscopic data. Analogues of the natural product were then synthesized and investigated for potential cytotoxic activity.
Acremolin is a natural product reported as a 1H-azirine-containing guanine derivative isolated from Acremonium strictum. Due to the known structural instability of 1H-azirines systems, the original assignment is highly improbable.