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Transcranial Brain Stimulation for Treatment of Psychiatric Disorders

Transcranial magnetic stimulation (TMS) was introduced in the mid 1980s in clinical neurophysiology to study the central motor pathways. Research has been exponentially increased since, and many different methods for brain stimulation have been considered during the last decade. This publication focuses on transcranially applied, non- or low-invasive interventions not requiring an implantable device, i.e. electroconvulsive therapy (ECT), repetitive TMS (rTMS) and transcranial direct current stimulation (tDCS). It provides an excellent overview on this spectrum of fascinating techniques. Many leading experts in this field have contributed to this book. A single chapter summarizes the state of the art in ECT. A series of chapters provides an overview on preclinical research in animals and neuroimaging findings with rTMS and reviews the evidence of efficacy and safety in various psychiatric disorders (affective disorders, schizophrenia and anxiety disorders) also including an article on the application of rTMS in nonpsychiatric diseases, i.e. Parkinson's disease, stroke, pain and tinnitus. Finally, separate reviews discuss very recent innovative approaches in the field of rTMS, i.e. magnetic seizure therapy, theta burst stimulation and deep rTMS. This publication will doubtlessly prove to be essential reading not only to researchers in this field, but also to psychiatrists, neurologists and other clinicians who consider applying these new methods in clinical settings

Basel, Karger, 2007, vol 23, pp 187–203 Theta Burst Stimulation Ying-Zu
Huanga, John C. Rothwellb aDepartment of Neurology, Chang Gung Memorial
Hospital and Chang Gung University College of Medicine, Taipei, Taiwan, ROC;
bSobell ...

Brain Stimulation

Chapter 46. Superficial brain stimulation in multiple sclerosis

Central motor conduction time (CMCT) is the most frequently studied measure derived from transcranial magnetic stimulation (TMS) in multiple sclerosis (MS); it is abnormal in 57–93% of patients. Addition of the triple stimulation technique and combining motor with other evoked potentials (EPs) increases sensitivity. Cross-sectional correlations of TMS measures with clinical assessments of motor dysfunction or global disability are high. Longitudinally, CMCT is sensitive to both worsening and improvement of motor function, showing its potential to detect therapeutic responses. Moreover, combined multimodal EPs are valid quantitative predictors of the clinical course over periods ranging from 2 to 14 years. Measures of transcallosal connectivity (ipsilateral silent period and interhemispheric inhibition) are altered even in early MS, and yield complementary information on subclinical changes. Pathological brain plasticity in MS has been demonstrated by paired associative stimulation studies revealing a compensatory role of the ipsilateral motor and premotor areas. Central motor fatigue is associated with reduced motor EP amplitudes and increased cortical silent periods in normal controls, whereas patients with MS suffering from subjective fatigue show various abnormalities in cortical modulation of the motor system.

Superficial brain stimulation in multiple sclerosis Regina Schlaeger Department
of Neurology, Hospitals of the University of Basel, Basel, Switzerland Martin
Hardmeier Department of Neurology, Hospitals of the University of Basel, Basel,
 ...

Brain Stimulation

The field of brain stimulation is expanding rapidly, with techniques such as DBS, TMS, and tDCS moving from the research community into clinical diagnosis and treatment. Clinical applications include treating disorders such as Parkinson's disease, dystonia, and even depression. The chapters of Brain Stimulation are written by leading international researchers and clinical specialists include coverage of techniques, modes of action and applications in physiology and therapeutics. The combination of research and clinical coverage will be of interest to neurologists, neurosurgeons, psychiatrists, neuroscientists, and health care workers. A comprehensive introduction and overview of deep brain stimulation (DBS) Coverage of DBS, transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) Details the basic science and research utility of DBS and clinical application

... School of Medicine, Stanford, CA, USA T.J. Foutz Department of Biomedical
Engineering, Case Western Reserve University, Cleveland, OH, USA P. Fuhr
Department of Neurology, Hospitals of the University of Basel, Basel, Switzerland
M.S. ...