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Writing and Developing Social Stories

This practical resource provides an introduction to the theory and practice of writing social stories. In addition, there are examples of successful stories to use as guides, as well as information and photocopiable resources for delivering training on the use of social stories. Based on detailed work carried out in homes, schools and pre-schools, this book offers practical support to anyone meeting the needs of a child or young adult with an autistic spectrum disorder. Social stories are short stories intended for children with autism to help them understand their social world and behave appropriately within it. The stories provide clear, concise and accurate information about what is happening in a specific situation, outlining both why it is happening and what a typical response might be. It is written by those directly supporting a child with autism and only successful stories are included in the book. The stories are infinitely flexible and adaptable to an individual child in an individual social situation. It covers children aged 3 to 16.

It is written by those directly supporting a child with autism and only successful stories are included in the book. The stories are infinitely flexible and adaptable to an individual child in an individual social situation.

New Theatre Quarterly 68: Volume 17

Provides an international forum where theatrical scholarship and practice can meet.

... impact political devolution might have on the rhetoric of Scottish cultural
criticism by paralleling feminist analysis of three plays by women premiered in
Scotland in 2000 with the flexible, even hybrid, model of the nation afford by
devolution, ...

User's manual for LINEAR, a FORTRAN program to derive linear aircraft models

Sejarah Islam lokal

History of Islam in Yogyakarta.

History of Islam in Yogyakarta.

Risalah membangun masyarakat Islam cemerlang Singapura

Building excellent Muslim community in Singapore through sociocultural and religious ethics.

Apakah pendirian Muslim terhadap tamadun-tamadun lain? Terbuka dalam ...
Tanpa ilmu tersebut, penulisan cendekiawan Islam tidak mampu disebar luas,
lantas diraih manfaatnya oleh jumlah pembaca yang lebih besar. 31 csty iilam ...

Guidelines for Constructing Consumption Aggregates for Welfare Analysis

In September 2001, staff from the World Bank and the International Monetary Fund met with the objective of strengthening collaboration between the two organizations in projects of civil service reform. This strengthened collaboration will have key benefits in ensuring consistency between the conflicting goals of the two organizations, establishing realistic objectives within the reform process, and maintaining a core set of wage and employment data. The principal conclusion arrived at was that World Bank and IMF staff should be engaging in collaboration earlier in the reform process. To guide the collaboration, six foundations were identified. These include: develop a medium-term fiscal framework; foster national ownership by making reforms politically feasible; focus and streamline conditionality; agree on sequencing and timing of reforms; and strengthen data collection. These principals will be tested for effectiveness in several focus countries.

Each survey is at least a little different from every other, so that the code that
follows would — at a minimum — have to be modified for each country to take
into account differences in structure of the questionnaire as well as to give due
consideration to each country's unique circumstances and institutions, types of
data collected in the survey, etc. Al includes the 6 Stata programs used to
construct the consumption aggregate from the Nepal Living Standards Survey (
NLSS) data, the ...

P53 Downregulates AKR1B10 as a Negative Feedback of AMPK Activity

Aldo-keto reductase 1 B10 (AKR1B10) is a secretory protein, overexpressed in human cancer cells in different cancers, such as hepatocellular carcinoma, lung squamous carcinoma, and lung adenocarcinoma in smokers. The author's recent study revealed that AKR1B10 may play an oncogenic role in cancer development and progression, but little is known of its expression or regulation. In this study, the author reveals a part of the regulatory mechanism by investigating the role of p53 transcription factor in regulating AKR1B10 expression level in colorectal cancer cell line, HCT-8, and hepatocellular carcinoma cell line, HepG2. In addition, this study found a negative feedback loop of p53 through AKR1B10 and AMPK. This study shows that AKR1B10 promoter contains four p53 binding sites within -804bp region of the promoter which is 4kb in full length. Mutations of p53 binding sites or knockdown of p53 expression by shRNA significantly increases the basal promoter activity and the protein expression of AKR1B10. Western blot showed that overexpression of p53 protein suppresses AKR1B10 expression level. Furthermore, the author demonstrates the direct interaction of p53 protein with its four binding sites ex vivo by chromatin immunoprecipitation assay. Also, EMSA assay further confirms the binding of this transcription factor protein with the first DNA binding site. The author's Luciferase assay showed that p53 suppresses AKR1B10 promoter activity in a dose dependent manner. While AMPK is known to be a p53 stimulator, our lab found that AMPK can be induced by AKR1B10. Together these results suggest that p53 transcription factor downregulates AKR1B10 as a negative feedback of AMPK activity.

While AMPK is known to be a p53 stimulator, our lab found that AMPK can be induced by AKR1B10. Together these results suggest that p53 transcription factor downregulates AKR1B10 as a negative feedback of AMPK activity.